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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CRKL All Species: 31.52
Human Site: S8 Identified Species: 63.03
UniProt: P46109 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46109 NP_005198.1 303 33777 S8 M S S A R F D S S D R S A W Y
Chimpanzee Pan troglodytes XP_001167996 296 33105 S8 M S S A R F D S S D R S A W Y
Rhesus Macaque Macaca mulatta XP_001086006 296 33190 S8 M S S A R F D S S D R S A W Y
Dog Lupus familis XP_849949 303 33840 S8 M S S A R F D S S D R S A W Y
Cat Felis silvestris
Mouse Mus musculus P47941 303 33812 S8 M S S A R F D S S D R S A W Y
Rat Rattus norvegicus Q5U2U2 303 33847 S8 M S S A R F D S S D R S A W Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507507 300 33196 S8 M S S A R F D S S D R G A W Y
Chicken Gallus gallus Q04929 305 33787 E8 M A G Q F D S E D R G S W Y W
Frog Xenopus laevis P87378 296 33391 E8 M A G N F D S E D R A S W Y W
Zebra Danio Brachydanio rerio NP_998703 305 33802 S8 M S S A R F D S S D R A S W Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9XYM0 271 31186 D8 M D T F D V S D R N S W Y F G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9NHC3 279 30860 P8 M T T N G F D P F E W R S F Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 95.3 97.3 N.A. 96.6 96.6 N.A. 90.4 60 61.7 82.6 N.A. 43.5 N.A. 27.7 N.A.
Protein Similarity: 100 96 96 98.6 N.A. 99 98.6 N.A. 94.3 71.8 72.9 90.8 N.A. 62.3 N.A. 45.2 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 13.3 13.3 86.6 N.A. 6.6 N.A. 26.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 33.3 33.3 100 N.A. 26.6 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 67 0 0 0 0 0 0 9 9 59 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 9 17 75 9 17 67 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 17 0 9 0 0 0 0 0 % E
% Phe: 0 0 0 9 17 75 0 0 9 0 0 0 0 17 0 % F
% Gly: 0 0 17 0 9 0 0 0 0 0 9 9 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 17 0 0 0 0 0 9 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 67 0 0 0 9 17 67 9 0 0 0 % R
% Ser: 0 67 67 0 0 0 25 67 67 0 9 67 17 0 0 % S
% Thr: 0 9 17 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 9 17 67 17 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 9 17 75 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _